The MCP-8 (Mast Cell Protease 8, Mcpt8) Antibody from MyBioSource.com is a Mouse, and Rat Monoclonal antibody to CD46, and CD46 molecule. This antibody recognizes Mouse, and Rat antigen. The MCP-8 (Mast Cell Protease 8, Mcpt8) Antibody has been validated for the following applications: Western Blot.
Description
mMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals